Thermodynamic Analysis of the Solubility of Sulfadiazine in (Acetonitrile 1-Propanol) Cosolvent Mixtures from 278.15 K to 318.15 K

Drug solubility is one of the most significant physicochemical properties as it related to drug design, formulation, quantification, recrystallization, and other processes, so understanding crucial for pharmaceutical industry. In this context, research presents thermodynamic analysis sulfadiazine (SD) in cosolvent mixtures {acetonitrile + 1-propanol} at 9 temperatures (278.15 K–318.15 K), which a widely used veterinary therapy, two solvents high relevance industry, respectively. The SD, an endothermic process where maximum was reached pure acetonitrile 318.15 K minimum 1-propanol 278.15 K. Although parameters propanol were similar, addition mixture leads positive effect on DS. As functions solution, strongly influenced by enthalpy, according enthalpy–entropy compensation analysis, enthalpy-driven intermediate rich entropy-driven acetonitrile.